At lower doses, the side effects include fatigue and gynecomastia (swelling of men’s breasts). Cyproterone acetate can also have an unfavourable effect on lipid profile and increases cardiovascular risk. Intramuscular injections of Cyproterone acetate have been found to reduce hot flashes drastically.
Oestrogens and Progesterones were some of the earliest therapies for treating hot flashes and were successful. Hot flashes can last for androgen deprivation therapy (ADT) treatment and can significantly impact the quality of life and sleep. Hot flashes have been linked to embarrassment, helplessness, and distress during treatment. Hot flashes are known to worsen with a longer duration of ADT and are worse in younger men with lower BMI.Īpproximately 80-90% of men on androgen deprivation therapy (ADT) experience hot flashes, with 27% reporting them as the most bothersome side effect. There is a positive correlation between hot flashes and luteinising hormone (LH) surges. The thermoregulatory centre in the hypothalamus can be reset by reducing sex hormones. The reduction of plasma sex hormones from normal levels can affect the functioning of brain neurotransmitters such as noradrenaline, serotonin, GABA, dopamine, and beta-endorphins.ADT effectively deprives prostate cancer cells of testosterone and hinders their growth. Hormonal treatment, called androgen deprivation therapy (ADT) in medical circles, uses drugs to block or reduce testosterone and other male sex hormones that support cancer growth. Prostate cancer cells rely on the hormone testosterone to grow.Some causes of hot flashes in prostate cancer are: However, it is common in men who have been castrated due to prostate cancer or are undergoing hormone therapy. Hot flashes and fatigue are not typically associated with prostate cancer.
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